Post-doctoral Fellow in LNP-assisted Gene-Editing for Neurodegeneration
University of Hong Kong
- Department
- Department of Pharmacology and Pharmacy (21300)
- Rank
- Postdoctoral
- Position type
- Full-time
- Reference
- 537605
- Start date
- As soon as possible
- Salary / grade
- Competitive salary commensurate with qualifications and experience.
- Application deadline
- 31 Jan 2027
Duties & Responsibilities
- Design and evaluate CRISPR-Cas9-based gene editing strategies for single and dual gene knockout in disease-relevant models.
- Formulate, characterize and optimize lipid nanoparticles for encapsulation and delivery of gene editing payloads.
- Conduct in vivo animal studies including administration of LNP-based therapeutics and disease progression monitoring.
- Perform behavioral studies and phenotypic assessments in disease mouse models to evaluate therapeutic efficacy.
- Apply immunohistochemistry and molecular analyses to determine targeting precision and quantify protein knockout.
- Support transcriptomic studies, collaborate internationally, and contribute to grant and manuscript writing.
Requirements & Qualifications
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, Neuroscience, Bioengineering, or related field.
- Strong research track record in gene editing or nanoparticle-based therapeutics with proven scientific writing skills.
- Hands-on expertise in CRISPR-Cas systems including guide RNA design and LNP formulation and characterization.
- Experience with in vivo experiments, behavioral studies, and cellular/molecular biology techniques such as western blotting and immunohistochemistry.
- Excellent written and spoken English with ability to work independently, problem-solve, and supervise students.
- Proficiency in IT skills for data management and capability to contribute to grant writing and funding applications.
Appointment
- Temporary, 1 year with possibility of renewal subject to funding availability and project progress.
Key Dates
- Posted date: 2026-10-12
- Closing date: 2027-01-31